Innoventric Secures $28.5M and Unveils Groundbreaking Tricuspid Regurgitation Treatment to Help Patients, Many of Whom Were Previously Untreatable

Reduces Treatment Risk By Eliminating the Need for Surgical Valve Replacement and General Anesthesia – Which Ensures Shorter Operations

 Innoventric, an Israel-based leader in transcatheter tricuspid regurgitation (TR) treatment, today announced a $28.5 million Series B funding round to advance its revolutionary cross-caval technology, bringing the total funds raised since inception to $41 million.

The round was led by RA Capital Management, with new investment from the European Investment Committee (EIC). Returning investors BRM Group, JG Private Equity, and Mivtach Shamir Holdings also participated, reinforcing their confidence in Innoventric’s path-breaking technology.

Innoventric has already successfully completed a first-in-human clinical trial in Europe, and performed many additional implantations — treating over 40 participants so far. Recently, the company received FDA clearance for an Early Feasibility Study (EFS) in the US, and patient enrollment is actively ongoing with the first US patients already treated. The funds raised will be used to advance clinical trials and expand regulatory approvals in the US and Europe.

Innoventric’s device addresses tricuspid regurgitation, a severe condition that impairs the cardiac blood flow, by replacing the native valve’s function through a heterotopic, cross-caval approach. With Innoventric, a prosthetic valve is anchored to the vena cava instead of the beating heart, so a complete seal is achieved without the risk of leakage or detachment. This method simplifies the implantation process and overcomes the anatomical complexities associated with traditional treatments. Positioned at the forefront of the $10 billion annual transcatheter heart valve replacement market, Innoventric’s technology is poised to transform tricuspid valve treatment.

The Innoventric device offers significant advantages, including broad patient applicability. Designed to accommodate various anatomies, it enables treatment for patients who are typically ineligible for tricuspid procedures. Its innovative anchoring technique provides secure attachment to the tubular superior vena cava (SVC) and inferior vena cava (IVC) rather than the beating heart, which minimizes risks such as leakage or detachment. The device also supports a streamlined procedure, as it can be implanted quickly without the need for echocardiography or general anesthesia, significantly enhancing success rates and reducing patient recovery time.

Amir Danino, CEO of Innoventric, stated: “Our mission is to revolutionize tricuspid regurgitation care with minimally invasive therapies that significantly improve patient outcomes. The strong backing from our investors, coupled with the progress we’ve achieved, underscores the need and huge potential of our approach to treat TR.”

Anurag Kondapalli, principal at RA Capital Management, said: “We are excited to support Innoventric as it looks to transform the approach to TR treatment. The strong outcomes from their European first-in-human trial demonstrate the immense potential of their anatomy-agnostic device to treat a broader range of patients who have lacked viable options. We are very impressesd with Innoventric’s technology and leadership, and believe their solution has the potential to significantly reshape the future of TR care.”

To learn more about Innoventric and its world leading approach, visit https://innoventric.com/.

Ctrdit: Innoventric